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A Reagent for Determining Optical Purities of Diols by Formation of Diastereomeric Arylboronate Esters
Author(s) -
Burgess Kevin,
Porte Alexander M.
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199411821
Subject(s) - diastereomer , reagent , derivatization , enantioselective synthesis , chemistry , diol , organic chemistry , combinatorial chemistry , chromatography , high performance liquid chromatography , catalysis
A remarkably simple arylboronic acid reagent for derivatization of diols enables the determination of the optical purity of diols by 1 H NMR spectroscopy by the formation of the corresponding esters 1 . This procedure could be particularly valuable as enantioselective bishydroxylations become more widely used for asymmetric syntheses.