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A Convergent Synthesis of 2,5‐ trans ‐Linked Oligo (tetrahydrofuran)s: Potential Building Blocks for a Polyether Helix with Ion Channel Activity
Author(s) -
Koert Ulrich,
Stein Matthias,
Harms Klaus
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199411801
Subject(s) - pentamer , tetrahydrofuran , convergent synthesis , chemistry , helix (gastropod) , ion , stereochemistry , combinatorial chemistry , organic chemistry , ecology , biochemistry , solvent , snail , biology
The C 2 ‐symmetric tetrahydrofuran pentamer 1 was prepared in enantiomerically pure form by a convergent synthesis. Compounds of this type are of interest for the construction of synthetic ion channels from polyether helices. TBDPS = t BuPh 2 Si.
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