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Binuclear Metal Complexes as Efficient Intermediaries in Biochemically Relevant Hydrolysis Reactions
Author(s) -
Göbel Michael W.
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199411411
Subject(s) - hydrolysis , formate , chemistry , dimethylformamide , catalysis , metal , combinatorial chemistry , metal ions in aqueous solution , ion , organic chemistry , solvent
Rates never before achieved for the hydrolysis of amides are attained by the Cu 2 (O 2 ) complex 1 , which converts dimethylformamide into the formate ion in seconds (half‐lives of amides in water are often several years!). The interacting Cu ions play an important role. Such simple model systems can provide insights into the structure–activity relationships of enzymes and even lead to the development of highly active catalysts.