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The First Total Syntheses of Taxol
Author(s) -
Wessjohann Ludger
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199409591
Subject(s) - total synthesis , natural product , milestone , chemistry , combinatorial chemistry , stereochemistry , nanotechnology , materials science , geography , archaeology
A milestone in natural product chemistry is the first total synthesis of taxol achieved independently of each other by the groups of R. A. Holton and K. C. Nicolaou. Taxol is at present the most promising anti‐cancer agent, and its synthesis is extremely demanding. It is highly unlikely that this climax will be the end of probably the greatest worldwide effort yet to synthesize a single compound.