A Convergent Total Synthesis of Calicheamicin γ       1    I | Zendy

Hitchcock Stephen A. | Zendy; Boyer Serge H. | Zendy; ChuMoyer Margaret Y. | Zendy; Olson Steven H. | Zendy; Danishefsky Samuel J. | Zendy

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A Convergent Total Synthesis of Calicheamicin γ 1 I

Author(s) -

Hitchcock Stephen A.,

Boyer Serge H.,

ChuMoyer Margaret Y.,

Olson Steven H.,

Danishefsky Samuel J.

Publication year - 1994

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199408581

Subject(s) - calicheamicin , aglycone , total synthesis , natural product , glycosylation , product (mathematics) , chemistry , glycosyl , convergence (economics) , combinatorial chemistry , computer science , stereochemistry , mathematics , glycoside , biology , biochemistry , geometry , myeloid leukemia , economics , immunology , economic growth

Ultimate convergence for the total synthesis of calicheamicin γ 1 Ihas been achieved thanks to a remarkable glycosidation between the glycosyl donor 2 and aglycone ent ‐ 1 (see preceeding communication; R = SSMe, ketal‐protected); after glycosidation the natural product is obtained in two steps.

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