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A Convergent Total Synthesis of Calicheamicin γ 1 I
Author(s) -
Hitchcock Stephen A.,
Boyer Serge H.,
ChuMoyer Margaret Y.,
Olson Steven H.,
Danishefsky Samuel J.
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199408581
Subject(s) - calicheamicin , aglycone , total synthesis , natural product , glycosylation , product (mathematics) , chemistry , glycosyl , convergence (economics) , combinatorial chemistry , computer science , stereochemistry , mathematics , glycoside , biology , biochemistry , geometry , myeloid leukemia , economics , immunology , economic growth
Ultimate convergence for the total synthesis of calicheamicin γ 1 Ihas been achieved thanks to a remarkable glycosidation between the glycosyl donor 2 and aglycone ent ‐ 1 (see preceeding communication; R = SSMe, ketal‐protected); after glycosidation the natural product is obtained in two steps.