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Resolution of Racemates by Distillation with Inclusion Compounds
Author(s) -
Kaupp Gerd
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199407281
Subject(s) - enantiomer , distillation , resolution (logic) , hexane , chemistry , alcohol , enantiomeric excess , organic chemistry , lattice (music) , chromatography , ether , vacuum distillation , enantioselective synthesis , catalysis , computer science , physics , artificial intelligence , acoustics
Will optical resolution by HPLC with chiral columns become obsolete? With a new technique, which should be amenable to upscaling, suspensions of crystalline host compounds such as 1 and 2 in hexane or water form 1:1 complexes with the one enantiomer of a racemic alcohol or ether such as 3 and 4 that fits best into its lattice. The two enantiomers can then be separated by vacuum distillation.