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Vanadium( II )‐ and Niobium( III )‐Induced, Diastereoselective Pinacol Coupling of Peptide Aldehydes to C 2 ‐Symmetrical HIV‐Protease Inhibitors
Author(s) -
Kammermeier Bernhard,
Beck Gerhard,
Jendralla Heiner,
Jacobi Detlev
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199406851
Subject(s) - pinacol , catalysis , chemistry , peptide , aryl , vanadium , protease , niobium , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , enzyme , biochemistry , alkyl
Potent inhibitors of HIV‐protease such as 1 can be produced on a kilogram scale by diastereoselective, reductive dimerization of homochiral peptide aldehydes. This is made possible by the use of niobium catalysts or vanadium catalysts generated in situ in the crucial reaction step. aryl = 1‐naphthyl.