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Activation of Glutathione Reductase by Light: A Novel Approach to Design Redox Photo‐Enzymes
Author(s) -
Willner Itamar,
Zahavy Eran
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199405811
Subject(s) - redox , glutathione , glutathione reductase , chemistry , electron transfer , photochemistry , isothiocyanate , enzyme , relay , reductase , gpx3 , biochemistry , biophysics , glutathione peroxidase , inorganic chemistry , biology , power (physics) , physics , quantum mechanics
Light‐induced electron transfer within a protein, coupled with chemical transformations, was achieved with the glutathione reductase modified by eosin isothiocyanate. The dye functions both as an initiator for the electron transfer and as a relay unit in the protein backbone that facilitates the electrical communication with the redox center at which the oxidized glutathione is reduced.