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Regioselective Synthesis and Antiviral Activity of Purine Nucleoside Analogues with Acyclic Substituents at N7
Author(s) -
Jähne Gerhard,
Kroha Herbert,
Müller Armin,
Helsberg Matthias,
Winkler Irvin,
Gross Gerhard,
Scholl Thomas
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199405621
Subject(s) - purine , regioselectivity , substituent , chemistry , stereochemistry , residue (chemistry) , nucleoside , derivative (finance) , combinatorial chemistry , biochemistry , enzyme , catalysis , financial economics , economics
A new class of antiviral compounds is heralded by purine derivative 1 , which in vitro tests showed to have good antiherpes action. This compound proves that, like the natural purine nucleosides with a cyclic residue at N9, derivatives with an acyclic substituent at N7 can also be active.