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Cyclosporin: A Li‐ and Ca‐Specific Ionophore!
Author(s) -
Bürger H. Michael,
Seebach Dieter
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199404421
Subject(s) - ionophore , alkaline earth metal , alkali metal , chemistry , membrane , metal , metal ions in aqueous solution , ion , inorganic chemistry , biophysics , biochemistry , organic chemistry , biology
The ionophoric properties of cyclosporin shed new light on its role in immunosuppresion : Cyclosporin transports Li + and Ca 2+ significantly faster than appropriate for their position in the series of alkali metal and alkaline‐earth metal ions, respectively. The migration of the picrates of these metals through a CH 2 Cl 2 solution of cyclosporin (which functions as a liquid membrane) has been examined.