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Catalytic Enantioselective CC Coupling—Allyl Transfer and Mukaiyama Aldol Reaction
Author(s) -
Bach Thorsten
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199404171
Subject(s) - enantioselective synthesis , catalysis , aldol reaction , chemistry , stoichiometry , enantiomer , chiral lewis acid , lewis acids and bases , organic chemistry , combinatorial chemistry
To obtain enantiomerically pure products without using stoichiometric quantities of chiral components is now possible for the title reactions [Eq. (a)]. Chiral Lewis acids M′X n are employed, which enable an excellent facial differentiation. In some cases these catalysts provide enantiomeric excesses greater than 95% and outstanding chemical yields.