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Cover Picture (Angew. Chem. Int. Ed. Engl. 4/1994)
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199403651
Subject(s) - cover (algebra) , int , polymer science , chemistry , computer science , engineering , programming language , mechanical engineering
The cover picture shows a balance with 1.5010 g of the enantiomerically pure, chiral ketone whose formula is given on the right‐hand side of the picture. This compound was synthesized on a preparative scale by the antibody‐catalyzed enantioselective hydrolysis of the enol ether shown on the left‐hand side. The monoclonal antibody was raised against a hapten (general structure in the box) which is an analogue of the transition state depicted at the top. Thus, catalytic antibodies (see for example the highlight by C. Leumann last year: Angew. Chem. 1993 , 105 , 1352; Angew. Chem. Int. Ed. Engl. 1993 , 32 , 1291) can be considered as practical tools for preparative chemistry. J.‐L. Reymond, J.‐L. Reber, and R. A. Lerner give details on upscaling on pp. 475–477.