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The Biosynthesis of Nitro Compounds: The Enzymatic Oxidation to Pyrrolnitrin of Its Amino‐Substituted Precursor
Author(s) -
Kirner Sabine,
van Pée KarlHeinz
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199403521
Subject(s) - chemistry , enzyme , nitro , biosynthesis , aryl , pseudomonas , biochemistry , in vitro , redox , organic chemistry , stereochemistry , bacteria , biology , alkyl , genetics
The enzymatic reaction arylNH 2 →arylNO 2 , the nonenzymatic counterpart of which requires drastic conditions, was previously hardly studied. Now a chloroperoxidase (CPOP) isolated from the bacterial species Pseudomonas has been found to catalyze not only halogenations in vitro, but also the oxidation of the precursor 1 to 2 .