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Amides as a New Type of Backbone Modification in Oligonucleotides
Author(s) -
De Mesmaeker Alain,
Waldner Adrian,
Lebreton Jacques,
Hoffmann Pascale,
Fritsch Valérie,
Wolf Romain M.,
Freier Susan M.
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199402261
Subject(s) - oligonucleotide , phosphodiester bond , amide , rna , chemistry , nucleic acid , combinatorial chemistry , dna , stereochemistry , biochemistry , gene
No decrease in the affinity for the complementary RNA target is observed when the natural phosphodiester linkages in oligonucleotides are replaced with amide units. This was found in investigations of oligonucleotides containing one or more modified components 1 . In addition these oligonucleotides are roughly ten times more resistant towards 3′‐exonucleases.