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Synthesis of Dihydroxyacetone Phosphate (and Isosteric Analogues) by Enzymatic Oxidation; Sugars from Glycerol
Author(s) -
Fessner WolfDieter,
Sinerius Gudrun
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199402091
Subject(s) - dihydroxyacetone phosphate , dihydroxyacetone , glycerol , chemistry , enzyme , phosphate , adduct , organic chemistry , catalysis , biochemistry
The combination of enzymes glycerol phosphate oxidase and catalase allows the efficient preparative oxidation of glycerol phosphate 1 (X = O) with elemental oxygen which yields dihydroxyacetone phosphate 2 (X = O). Phosphate 2 can be added to various aldehydes in a one‐flask, enzyme‐catalyzed reaction to furnish 3 (X = O). Isosteric analogues of glycerol phosphate 1 (X = CH 2 , NH, S) can be converted into the corresponding adducts 3 .