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The Sialyl Lewis x Group and its Analogues as Ligands for Selectins: Chemoenzymatic Syntheses and Biological Functions
Author(s) -
Giannis Athanassios
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199401781
Subject(s) - selectin , sialyl lewis x , chemistry , ligand (biochemistry) , stereochemistry , carbohydrate , group (periodic table) , adhesion , biochemistry , organic chemistry , receptor
Inhibitors of leukocyte adhesion have potential as antiphlogistics, antithrombotics, and immunosuppressants. The interaction of selectins and their membrane‐bound carbohydrate ligands is decisive for the initial phase of adhesion, and the sialyl Lewis x group 1 is a common ligand for all three selectins. Thus the ingenious chemoenzymatic synthesis of 1 and its analogues reported recently by Paulson, Wong, et al. has received much attention.