Premium
Synthesis and Reactivity of α,α‐Dichloroglycyl Peptides
Author(s) -
Jaroch Stefan,
Schwarz Thomas,
Steglich Wolfgang,
Zistler Peter
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199317711
Subject(s) - heteroatom , residue (chemistry) , peptide , chemistry , glycine , reactivity (psychology) , amino acid , stereochemistry , ring (chemistry) , amino acid residue , combinatorial chemistry , organic chemistry , peptide sequence , biochemistry , medicine , alternative medicine , pathology , gene
Novel peptide derivatives like 1 with an α,α‐disubstituted (heteroatom substituents) glycine residue can be prepared from α,α‐dichloroglycyl peptides. These compounds, in turn, are obtained from 4,4‐di(alkylthio)5(4 H )‐oxazolones by ring‐opening with amino acid esters and subsequent reaction with SO 2 Cl 2 .