The Mechanism of Anaerobic, Radical‐Induced DNA Strand Scission | Zendy

Giese Bernd | Zendy; BeyrichGraf Xenia | Zendy; Burger Jutta | Zendy; Kesselheim Christoph | Zendy; Senn Martin | Zendy; Schäfer Thomas | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

The Mechanism of Anaerobic, Radical‐Induced DNA Strand Scission

Author(s) -

Giese Bernd,

BeyrichGraf Xenia,

Burger Jutta,

Kesselheim Christoph,

Senn Martin,

Schäfer Thomas

Publication year - 1993

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199317421

Subject(s) - radical , chemistry , bond cleavage , thymine , photochemistry , dna , cleavage (geology) , methanol , stereochemistry , organic chemistry , catalysis , biochemistry , geotechnical engineering , fracture (geology) , engineering

After selective generation of the mononucleotide radical 1 , the formation and reactions of radical cation 2 could be studied. Trapping with allyl alcohol, which is known to trap both cations and radicals, gave primarily the bicyclic product 3 . With methanol several intermediates could be trapped, the hydrolysis products of which correspond to DNA cleavage products. 4′‐Deoxyribonucleotide radicals are proposed as intermediates in radical‐induced DNA strand scission. ℗ P(O)(OEt) 2 , b thymine.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research