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Phosphinic Acid‐Based C 2 ‐Symmetrical Inhibitors of HIV‐Protease **
Author(s) -
Peyman Anusch,
Buidt KarlHeinz,
Spanig Jörg,
Ruppert Dieter
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199317201
Subject(s) - protease , peptide , hydrolysis , hiv 1 protease , human immunodeficiency virus (hiv) , enzyme , chemistry , stereochemistry , combinatorial chemistry , biochemistry , virology , biology
As analogues of the transition state of peptide hydrolysis , phosphinic acid groups can be incorporated in a C 2 ‐symmetrical peptide environment based on the geometry of the HIV‐protease. This leads to compounds such as 1 , potent inhibitors of this key enzyme of the AIDS pathogens. R = 1‐naphthyl.
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