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Regiospecific Alkylation of 6‐Chloropurine and 2,6‐Dichloropurine at N7 by Transient Protection of N3/N9 by Methylcobaloxime
Author(s) -
Dalby Christine,
Bleasdale Christine,
Clegg William,
Elsegood Mark R. J.,
Golding Bernard T.,
Griffin Roger J.
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199316961
Subject(s) - alkylation , guanine , chemistry , transient (computer programming) , combinatorial chemistry , medicinal chemistry , stereochemistry , biochemistry , nucleotide , computer science , catalysis , gene , operating system
Suitable as starting materials for the synthesis of 2‐ and 6‐substituted adenine and guanine derivatives , which are potential enzyme inhibitors, are the 7‐alkylpurines 2 (XH, Cl; RPhCH 2 , PhCOCH 2 , CH 2 CHCH 2 , CH 3 COCH 2 ). These alkylpurines can be prepared from 1 (XH, Cl) regiospecifically according to a process that is based on the elaboration of a reaction discovered by Marzilli et al.