Premium
Got the Flu? Try a Designer Agent Derived from a Sugar
Author(s) -
Unverzagt Carlo
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199316911
Subject(s) - sialidase , replication (statistics) , sugar , virus , viral replication , virology , chemistry , computational biology , pharmacology , neuraminidase , biochemistry , biology
Even in nanomolar concentrations inhibitor 1 halts the replication of the influenza virus and thus introduces an impressive improvement of four orders of magnitude over known inhibitors of influenza sialidase. The design of inhibitor 1 resulted from molecular modeling studies based on the X‐ray structure of a sialidase‐inhibitor complex. The pharmaceutical industry has lately shown increased interest in drugs derived from sugars.