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Synthesis of a Nine‐Membered Cyclic Analogue of the Neocarzinostatin Chromophore and Its DNA‐Cleaving Activity
Author(s) -
Takahashi Takashi,
Tanaka Hiroshi,
Hirai Yoshimasa,
Doi Takayuki,
Yamada Haruo,
Shiraki Takashi,
Sugiura Yukio
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199316571
Subject(s) - neocarzinostatin , chromophore , chemistry , stereochemistry , dna , wittig reaction , combinatorial chemistry , biochemistry , photochemistry
The highly strained but relatively stable analogue 1 of the neocarzinostatin chromophore was synthesized by a transannular [2,3]‐Wittig rearrangement and characterized. Diyne 1 is the first analogue of this type with DNA cleaving activity and may thus have potential as an anticancer agent.