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Parallels and Decisive Differences in Vitamin B 12 Biosyntheses
Author(s) -
Blanche Francis,
Thibaut Dennis,
Debussche Laurent,
Hertle Ralf,
Zipfel Franz,
Müller Gerhard
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199316511
Subject(s) - biosynthesis , cobalt , biochemistry , chemistry , propionibacterium , paracoccus denitrificans , stereochemistry , biology , bacteria , organic chemistry , enzyme , genetics
Single reactions that are, in principle, similar to those in the cobalt‐free biosynthesis of hydrogenbyrinic acid ( 1 ) in the aerobe P. denitrificans , but with cobalt‐coordinated substrates, occur in the biosynthesis of cobyrinic acid ( 2 ) in the anaerobe P. shermanii . This information was obtained from incorporation experiments with 3 H/ 14 C doubly labeled precursors from the biosynthetic pathway of P. denitrificans . Previously it had been established that in P. shermanii and the biosynthesis of 2 , the cobalt ion is incorporated much earlier than in P. denitrificans .