The First Example of an Increase in the Enantioselectivity of a Chemical Reaction in the Presence of a Chiral Lewis Acid under High Pressure | Zendy

Tietze Lutz F. | Zendy; Ott Christian | Zendy; Gerke Kerstin | Zendy; Buback Michael | Zendy

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The First Example of an Increase in the Enantioselectivity of a Chemical Reaction in the Presence of a Chiral Lewis Acid under High Pressure

Author(s) -

Tietze Lutz F.,

Ott Christian,

Gerke Kerstin,

Buback Michael

Publication year - 1993

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199314851

Subject(s) - lewis acids and bases , intramolecular force , enantiomer , chemistry , chiral lewis acid , bar (unit) , enantioselective synthesis , diels–alder reaction , stereochemistry , medicinal chemistry , organic chemistry , catalysis , physics , meteorology

The enantioselectivity increases from 4.5 to 20.4% ee in favor of the (–)‐enantiomer in the intramolecular hetero‐Diels‐Alder reaction of 1 , which provides 2 and 3 when the pressure is increased from 1 to 5000 bar. A chiral Lewis acid is also employed in this reaction.

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