Vitamin D 3  Synthetic Studies: Enantiospecific Synthesis of the CD Ring Fragment | Zendy

Clasby Martin C. | Zendy; Craig Donald | Zendy; Marsh Andrew | Zendy

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Vitamin D 3 Synthetic Studies: Enantiospecific Synthesis of the CD Ring Fragment

Author(s) -

Clasby Martin C.,

Craig Donald,

Marsh Andrew

Publication year - 1993

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199314441

Subject(s) - pulegone , intramolecular force , chemistry , fragment (logic) , vitamin , stereochemistry , cycloaddition , ring (chemistry) , vitamin d and neurology , combinatorial chemistry , organic chemistry , biochemistry , biology , chromatography , essential oil , computer science , programming language , endocrinology , catalysis

The activity of highly oxygenated derivatives of vitamin D 3 in cancer and psoriasis therapies makes these compounds attractive synthetic goals. Here the vitamin D 3 building block 3 was synthesized enantiospecifcally from (+)‐( R )pulegone ( 1 ). The intramolecular cycloaddition of 2 is a key step in the reaction.

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