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Copper‐Catalyzed 1,4‐Additions of Trialkylaluminum Compounds to Enones
Author(s) -
Westermann Jürgen,
Nickisch Klaus
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199313681
Subject(s) - reagent , catalysis , stoichiometry , cuprate , chemistry , copper , transformation (genetics) , organic chemistry , materials science , biochemistry , gene , optoelectronics , doping
Faster than the competing attack at the carbonyl group is the Cu‐catalyzed 1,4‐addition of trialkylaluminum compounds to α, β‐unsaturated ketones [Eq. (a)]. Previously this transformation succeeded only with stoichiometric amounts of cuprate reagents. R = Me, Et; X = Br, Br 2 , CN.
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