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Aminocyclodextrins as Selective Hosts with Several Binding Sites for Nucleotides
Author(s) -
Eliseev Alexey V.,
Schneider HansJörg
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199313311
Subject(s) - nucleotide , nucleobase , chemistry , stereochemistry , sugar , crystallography , organic chemistry , biochemistry , dna , gene
A simultaneous discrimination between 3′‐ and 5′‐phosphates, 2′‐oxy‐ and 2′‐deoxyriboses and nucleobases of nucleotides is made possible by the use of β‐cyclodextrins with ammonio substituents in the 6 position; the corresponding host–guest complex (shown schematically) forms in water in the process. NMR spectroscopic investigations show that the sugar unit is found inside the cyclodextrin cavity.