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Selective Pd 0 ‐Mediated CC Bond Constructions on the Imidazole Ring of L ‐Histidine: A Practical Approach to the Synthesis of Diphthamide and Related Histidine Analogues
Author(s) -
Evans David A.,
Bach Thorsten
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199313261
Subject(s) - imidazole , histidine , ring (chemistry) , chemistry , stereochemistry , coupling (piping) , atom (system on chip) , combinatorial chemistry , materials science , organic chemistry , amino acid , computer science , biochemistry , metallurgy , embedded system
A simple access to histidines that contain a carbon branch at the C2 atom of the imidazole ring is provided by reaction (a). The protected monoiodo histidine 1 is therefore a versatile coupling partner.
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