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Synthesis of 4‐Deoxyaklanonic acid and Its Microbial Conversion into Anthracyclinones
Author(s) -
Krohn Karsten,
Roemer Ernst,
Top Michael,
Wagner Christina
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199311511
Subject(s) - biotransformation , glycosidic bond , chemistry , mutant , streptomyces , stereochemistry , combinatorial chemistry , biochemistry , organic chemistry , biology , bacteria , enzyme , gene , genetics
With a mutant strain of Streptomyces galilaeus , a cinerubin producer, the unnatural 4‐deoxyaklanoic acid 1 can be converted into the enantiomerically pure 4‐deoxyaklavinones 2 and 3 . Through this combination of chemical synthesis and multistep biotransformation, the preparation of glycosidic anthracyclines should be possible, for which improved antitumor properties are expected.