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Catalytic Hydrogenation with Rhodium Complexes Containing dipamp‐pyrphos Hybrid Ligands
Author(s) -
Nagel Ulrich,
Krink Thomas
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199310521
Subject(s) - rhodium , catalysis , ligand (biochemistry) , asymmetric hydrogenation , pyrrolidine , chemistry , enantiomer , chiral ligand , enantioselective synthesis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , receptor , biochemistry
Very high enantiomeric excesses are more easily achieved when the catalyst contains a C 2 ‐symmetric ligand as a chiral inductor—this, however, does not hold for hydrogenation, catalyzed by rhodium complexes with 3,4‐bis(phosphino)pyrrolidine ligands (e.g., 1 ). In the hydrogenation of ( Z )‐α‐acetoamidocinnamic acid the results obtained with the asymmetric ligand are similar to those with the C 2 ‐symmetric ligands. Boc = tert ‐butoxycarbonyl.