Premium
One‐Flask Synthesis of Propargylic Alcohols from Organolithium Reagents, N,N ‐Disubstituted Amides, and Acetylenes
Author(s) -
Hwu Jih Ru,
Hakimelahi Gholam Hosein,
Wong Fung Fuh,
Lin Chun Chieh
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199306081
Subject(s) - phenylacetylene , reagent , propargyl , amide , chemistry , solvent , organic chemistry , combinatorial chemistry , catalysis
Good to excellent yields of propargyl alcohols are obtained in a new one‐flask reaction at room temperature [Eq. (a)]. The order of addition of the reagents is very important; the organolithium compound must be added to phenylacetylene and the amide, which also functions as the solvent, otherwise the yields sink drastically.