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Selective Cleavage of a 35‐mer Single‐Stranded DNA Containing the Initiation Codon of the TAT Gene of HIV‐1 by a Tailored Cationic Manganese Porphyrin
Author(s) -
Pitié Marguerite,
Casas Christiane,
Lacey C. Jeffrey,
Pratviel Geneviève,
Bernadou Jean,
Meunier Bernard
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199305571
Subject(s) - nuclease , oligonucleotide , dna , cleavage (geology) , cationic polymerization , chemistry , gene , manganese , microbiology and biotechnology , porphyrin , biology , stereochemistry , biochemistry , polymer chemistry , paleontology , fracture (geology) , organic chemistry
The recognition and cleavage of DNA is highly selective when the cleaver is the conjugate from the chemical nuclease 1 and a 19‐mer vector. This is shown on a 35‐mer complementary DNA target, which contained the initiation colon of HIV‐I TAT. Such reactive antisense oligonucleotides invite further investigation as potential antiviral agents. M = Mn III (H 2 O), X = O(CH 2 ) 4 C(O)H, R = N = methylpyridinio.