Selective Cleavage of a 35‐mer Single‐Stranded DNA Containing the Initiation Codon of the TAT Gene of HIV‐1 by a Tailored Cationic Manganese Porphyrin | Zendy

Pitié Marguerite | Zendy; Casas Christiane | Zendy; Lacey C. Jeffrey | Zendy; Pratviel Geneviève | Zendy; Bernadou Jean | Zendy; Meunier Bernard | Zendy

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Selective Cleavage of a 35‐mer Single‐Stranded DNA Containing the Initiation Codon of the TAT Gene of HIV‐1 by a Tailored Cationic Manganese Porphyrin

Author(s) -

Pitié Marguerite,

Casas Christiane,

Lacey C. Jeffrey,

Pratviel Geneviève,

Bernadou Jean,

Meunier Bernard

Publication year - 1993

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199305571

Subject(s) - nuclease , oligonucleotide , dna , cleavage (geology) , cationic polymerization , chemistry , gene , manganese , microbiology and biotechnology , porphyrin , biology , stereochemistry , biochemistry , polymer chemistry , paleontology , fracture (geology) , organic chemistry

The recognition and cleavage of DNA is highly selective when the cleaver is the conjugate from the chemical nuclease 1 and a 19‐mer vector. This is shown on a 35‐mer complementary DNA target, which contained the initiation colon of HIV‐I TAT. Such reactive antisense oligonucleotides invite further investigation as potential antiviral agents. M = Mn III (H 2 O), X = O(CH 2 ) 4 C(O)H, R = N = methylpyridinio.

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