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Enantioselective Synthesis of α‐Amino Acetals and α‐Amino Acids by Nucleophilic 1,2‐Addition to Diethoxyacetaldehyde SAMP Hydrazone
Author(s) -
Enders Dieter,
Funk Rudolf,
Klatt Martin,
Raabe Gerhard,
Hovestreydt Eric R.
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199304181
Subject(s) - enantioselective synthesis , hydrazone , nucleophilic addition , chemistry , amino acid , nucleophile , stereochemistry , organic chemistry , catalysis , biochemistry
The nucleophilic 1,2‐addition of organocerium compounds to α‐SAMP/RAMP hydrazone acetals 1 is the basis of a new, highly enantioselective route to synthetically versatile α‐amino acetals 2 and α‐amino acids 3 . R = Me, Et, n Pr, i Pr, n Bu, t Bu, Ph.
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