Nickel( III )‐Promoted DNA Cleavage with Ambient Dioxygen | Zendy

Cheng ChienChung | Zendy; Rokita Steven E. | Zendy; Burrows Cynthia J. | Zendy

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Nickel( III )‐Promoted DNA Cleavage with Ambient Dioxygen

Author(s) -

Cheng ChienChung,

Rokita Steven E.,

Burrows Cynthia J.

Publication year - 1993

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199302771

Subject(s) - nickel , chemistry , radical , cleavage (geology) , reactivity (psychology) , dna , oxygen , stereochemistry , photochemistry , organic chemistry , biochemistry , materials science , medicine , alternative medicine , pathology , fracture (geology) , composite material

Oxygen‐sensitive nickel( II ) complexes with macrocyclic ligands promote DNA cleavage without additional oxidants, initiators, or irradiation. The reaction does not involve OH radicals, but superoxidoNi III complexes may play a role. The reactivity of the nickel complexes is highly dependent on the substituents on the ligands, which may allow fine‐tuning for in vivo applications. R 1 ,R 2 e.g. F, H.

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