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Nickel( III )‐Promoted DNA Cleavage with Ambient Dioxygen
Author(s) -
Cheng ChienChung,
Rokita Steven E.,
Burrows Cynthia J.
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199302771
Subject(s) - nickel , chemistry , radical , cleavage (geology) , reactivity (psychology) , dna , oxygen , stereochemistry , photochemistry , organic chemistry , biochemistry , materials science , medicine , alternative medicine , pathology , fracture (geology) , composite material
Oxygen‐sensitive nickel( II ) complexes with macrocyclic ligands promote DNA cleavage without additional oxidants, initiators, or irradiation. The reaction does not involve OH radicals, but superoxidoNi III complexes may play a role. The reactivity of the nickel complexes is highly dependent on the substituents on the ligands, which may allow fine‐tuning for in vivo applications. R 1 ,R 2 e.g. F, H.