Total Synthesis of (−)‐Pyrimidoblamic Acid and Deglycobleomycin A 2 | Zendy

Boger Dale L. | Zendy; Menezes Royce F. | Zendy; Honda Takeshi | Zendy

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Total Synthesis of (−)‐Pyrimidoblamic Acid and Deglycobleomycin A 2

Author(s) -

Boger Dale L.,

Menezes Royce F.,

Honda Takeshi

Publication year - 1993

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199302731

Subject(s) - bleomycin , imine , pyrimidine , total synthesis , chemistry , antibiotics , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , biochemistry , medicine , chemotherapy , surgery

Bleomycin is an important antibiotic for the treatment of cancer. Now the completion of the total synthesis of the aglycon 1 from bleomycin A 2 , the major component of bleomycin, has been achieved. The decisive steps are the construction of the pyrimidine part by an inverse‐electron‐demand Diels–Alder reaction and the diastereoselective addition of a stannous enolate to an imine group.

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