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S ‐Glycosylated Cyclic Peptides
Author(s) -
Gerz Manfred,
Matter Hans,
Kessler Horst
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199302691
Subject(s) - cyclic peptide , chemistry , molecular dynamics , stereochemistry , combinatorial chemistry , computational chemistry , biochemistry , peptide
The high chemical and enzymatic stability of thioglycosides stimulated the synthesis of S ‐glycosylated cyclopeptides. The structural properties of this new class of compounds were established by conformational analysis with 2D NMR methods and molecular dynamics calculations. These substances are of interest for the development of site‐specific drugs.