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Enantioselective Transition Metal‐Catalyzed Hydrogenation for the Asymmetric Synthesis of Amines
Author(s) -
Bolm Carsten
Publication year - 1993
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199302321
Subject(s) - enantioselective synthesis , transition metal , catalysis , asymmetric hydrogenation , enantiomer , selectivity , noyori asymmetric hydrogenation , homogeneous , chemistry , optically active , metal , enantiomeric excess , organic chemistry , combinatorial chemistry , physics , thermodynamics
The great preparative potential of chiral transition metal complexes is again illustrated by the homogeneous asymmetrical hydrogenation of CN bonds which so far–in contrast to the hydrogenation of functionalized olefins or ketones–could be carried out with only a moderate selectivity. Both with the catalyst system Rh I ‐ 1 and also with the ansa ‐titanocene complex 2 optically active amines could be produced in high enantiomeric excesses.