Diastereoselective Three‐Center Michael Addition of β‐Ketoesters to Prostereogenic α,β‐Unsaturated Carbonyl Compounds Catalyzed by K 2 CO 3  or Cs 2 CO 3 | Zendy

Ouvrard Nicole | Zendy; Rodriguez Jean | Zendy; Santelli Maurice | Zendy

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Diastereoselective Three‐Center Michael Addition of β‐Ketoesters to Prostereogenic α,β‐Unsaturated Carbonyl Compounds Catalyzed by K 2 CO 3 or Cs 2 CO 3

Author(s) -

Ouvrard Nicole,

Rodriguez Jean,

Santelli Maurice

Publication year - 1992

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199216511

Subject(s) - cryptand , catalysis , center (category theory) , chemistry , quaternary carbon , medicinal chemistry , addition reaction , carbon fibers , stereochemistry , organic chemistry , enantioselective synthesis , crystallography , materials science , composite number , composite material , ion

The stereocontrolled construction of three contiguous quaternary and tertiary carbon atoms is possible by the title reaction [Eq. (a)]. The diastereoselectivity can be reversed by the addition of crown ethers or other cryptands. R 1 = Me, t Bu, Bz; R 2 = H, Me.

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