A Phenoxy‐Bridged Homodinuclear Zn Complex with an Unusual Coordination Sphere; Model Compound for the Active Site of Phospholipase C | Zendy

Uhlenbrock Stefan | Zendy; Krebs Bernt | Zendy

Premium

A Phenoxy‐Bridged Homodinuclear Zn Complex with an Unusual Coordination Sphere; Model Compound for the Active Site of Phospholipase C

Author(s) -

Uhlenbrock Stefan,

Krebs Bernt

Publication year - 1992

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199216471

Subject(s) - active site , carboxylate , chemistry , stereochemistry , molecule , coordination sphere , atom (system on chip) , catalysis , crystallography , crystal structure , biochemistry , organic chemistry , computer science , embedded system

The imitation of not only the structure but also the function of the active site of the metalloenzyme phospholipase C seems to have been achieved with complex 1 (O w = OH 2 ). The two Zn atoms in 1 are bridged by a phenoxy and a carboxylate group. In addition, one Zn atom binds an H 2 O molecule, which is important for the catalytic process.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research