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DNA Recognition by Hybrid Oligoether–Oligodeoxynucleotide Macrocycles
Author(s) -
Rumney Squire,
Kool Eric T.
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199216171
Subject(s) - oligonucleotide , dna , adduct , chemistry , combinatorial chemistry , biochemistry , organic chemistry
Exceptionally resistant to nucleases , the 1:1 adducts of single‐stranded oligonucleotides and cyclic oligoether–oligonucleotide hybrid compounds form triple‐helical structures. The picture on the right shows schematically the binding in these systems.