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A Milestone in Genome Sequencing: The Complete DNA Sequence of the Yeast Chromosome III
Author(s) -
Winnacker ErnstL.
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199215781
Subject(s) - genetics , gene , chromosome , biology , genome , sequence (biology) , human genome , complete sequence , dna sequencing , base pair , whole genome sequencing , computational biology
315357 Base pairs in length , chromosome III of baker's yeast was sequenced by 147 scientists from 35 European laboratories at a cost of approximately DM 10 per base pair. The sequence contains 182 open reading frames coding for proteins more than 100 amino acids long. Until now, the classical genetic map of this chromosome had listed only 34 genes, that is, only 20% of the actual number of genes. If one extrapolates this result to the human genome, the estimated number of our genes must be revised dramatically upwards, to 500 000 or more.