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Crosslinking of Adjacent Guanine Residues in an Oligonucleotide by cis ‐[Pt(NH 3 ) 2 (H 2 O) 2 ] 2+ : Kinetic Analysis of the Two‐Step Reaction
Author(s) -
Gonnet Florence,
Kozelka Jiři,
Chottard JeanClaude
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199214831
Subject(s) - oligonucleotide , guanine , chemistry , kinetic energy , stereochemistry , reaction rate constant , unit (ring theory) , crystallography , kinetics , mathematics , physics , nucleotide , biochemistry , dna , quantum mechanics , gene , mathematics education
Why does cisplatin bind preferentially to GG units in oligonucleotides? The development of a new method which enables the determination of the four rate constants of the two‐step reaction between an oligonucleotide containing a GpG unit and cis‐[Pt(NH 3 ) 2 (H 2 O) 2 ] 2+ has brought us closer to the solution of this puzzle.