Crosslinking of Adjacent Guanine Residues in an Oligonucleotide by  cis ‐[Pt(NH 3 ) 2 (H 2 O) 2 ] 2+ : Kinetic Analysis of the Two‐Step Reaction | Zendy

Gonnet Florence | Zendy; Kozelka Jiři | Zendy; Chottard JeanClaude | Zendy

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Crosslinking of Adjacent Guanine Residues in an Oligonucleotide by cis ‐[Pt(NH 3 ) 2 (H 2 O) 2 ] 2+ : Kinetic Analysis of the Two‐Step Reaction

Author(s) -

Gonnet Florence,

Kozelka Jiři,

Chottard JeanClaude

Publication year - 1992

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199214831

Subject(s) - oligonucleotide , guanine , chemistry , kinetic energy , stereochemistry , reaction rate constant , unit (ring theory) , crystallography , kinetics , mathematics , physics , nucleotide , biochemistry , dna , quantum mechanics , gene , mathematics education

Why does cisplatin bind preferentially to GG units in oligonucleotides? The development of a new method which enables the determination of the four rate constants of the two‐step reaction between an oligonucleotide containing a GpG unit and cis‐[Pt(NH 3 ) 2 (H 2 O) 2 ] 2+ has brought us closer to the solution of this puzzle.

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