N ‐Perbenzylation of Oligopeptides with P4‐Phosphazene Base; A New Protecting‐Group Technique for Modification and Solubilization of Peptides in Apolar Organic Solvents | Zendy

Pietzonka Thomas | Zendy; Seebach Dieter | Zendy

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N ‐Perbenzylation of Oligopeptides with P4‐Phosphazene Base; A New Protecting‐Group Technique for Modification and Solubilization of Peptides in Apolar Organic Solvents

Author(s) -

Pietzonka Thomas,

Seebach Dieter

Publication year - 1992

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199214811

Subject(s) - phosphazene , chemistry , oligopeptide , base (topology) , solubilization , peptide , bromide , organic base , organic chemistry , protecting group , biochemistry , polymer , alkyl , mathematical analysis , mathematics

Even sparingly soluble peptides can be perbenzylated with P4‐phosphazene base/benzyl bromide. The products of type A are readily soluble in organic solvents and can be used for further modifications of the peptide framework. Debenzylation is achieved by treatment with sodium in liquid nitrogen.

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