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Synthesis of Esterase‐resistant 9‐ O ‐Acetylated Polysialoside as Inhibitor of Influenza C Virus Hemagglutinin
Author(s) -
Roy René,
Andersson Fredrik O.,
Harms Günter,
Kelm Sørge,
Schauer Roland
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199214781
Subject(s) - hemagglutinin (influenza) , sialic acid , chemistry , virus , influenza a virus , virology , adhesion , acetylation , host (biology) , microbiology and biotechnology , biology , biochemistry , organic chemistry , gene , ecology
N ‐acrylolated thioglycosides of sialic acid , for example 1 , can be treated with acrylamide to give glycopolymers. These new thioglycosides hinder the adhesion of influenza C virus to the host cell, but are resistant to viral esterases, which makes them interesting in the design of medication against influenza C infections. X = S, R = H, R′ = Me.