Synthesis of Esterase‐resistant 9‐ O ‐Acetylated Polysialoside as Inhibitor of Influenza C Virus Hemagglutinin | Zendy

Roy René | Zendy; Andersson Fredrik O. | Zendy; Harms Günter | Zendy; Kelm Sørge | Zendy; Schauer Roland | Zendy

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Synthesis of Esterase‐resistant 9‐ O ‐Acetylated Polysialoside as Inhibitor of Influenza C Virus Hemagglutinin

Author(s) -

Roy René,

Andersson Fredrik O.,

Harms Günter,

Kelm Sørge,

Schauer Roland

Publication year - 1992

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199214781

Subject(s) - hemagglutinin (influenza) , sialic acid , chemistry , virus , influenza a virus , virology , adhesion , acetylation , host (biology) , microbiology and biotechnology , biology , biochemistry , organic chemistry , gene , ecology

N ‐acrylolated thioglycosides of sialic acid , for example 1 , can be treated with acrylamide to give glycopolymers. These new thioglycosides hinder the adhesion of influenza C virus to the host cell, but are resistant to viral esterases, which makes them interesting in the design of medication against influenza C infections. X = S, R = H, R′ = Me.

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