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Synthesis and Biological Activity of D ‐3‐Deoxy‐3‐Fluorophosphatidylinositol—A New Direction in the Design of non‐DNA Targeted Anticancer Agents
Author(s) -
Kozikowski Alan P.,
Tückmantel Werner,
Powis Garth
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199213791
Subject(s) - inositol , dna , derivative (finance) , dna synthesis , inositol phosphate , biochemistry , chemistry , biology , computational biology , stereochemistry , microbiology and biotechnology , receptor , financial economics , economics
myo ‐Inositol causes no disruption in the growth‐inhibiting effect of the phos‐phatidylinositol (Ptdlns) derivative 1 . This first synthetic Ptdlns analogue with a myo ‐inositol configuration may point the way to new anti‐cancer agents based on the interruption of Pdtlns signaling, which do not inhibit cell growth by interaction with DNA.