Premium
Interactions Between Acyclic and Cyclic Peralkylammonium Compounds and DNA
Author(s) -
Schneider HansJörg,
Blatter Thomas
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199212071
Subject(s) - dna , hydrogen bond , ionic bonding , chemistry , protonation , yield (engineering) , salt (chemistry) , ion , intercalation (chemistry) , stereochemistry , crystallography , inorganic chemistry , organic chemistry , biochemistry , molecule , materials science , metallurgy
Increments of 5 ± 1 kJmol −1 per salt bridge satisfactorily yield the energy of ionic interactions between polyamines and calf thymus DNA. This value lies in the same range as those of numerous inorganic and organic ion pairs. Peralkylated polyamines have almost the same affinity for DNA as protonated polyamines; hydrogen bonds thus have little effect on the binding. Relatively rigid azoniacyclophanes sometimes have a higher affinity although the arene units are not intercalated.