trans ‐2‐ tert ‐Butylcyclohexanol, a Simple Selectively Optimized Cyclohexanol Auxiliary

An economical auxiliary comparable to 8‐phenylmenthol , trans ‐2‐ tert ‐butylcyclohexanol ( 1 ) was derived as a “structurally minimized” cyclohexanol with an optimized induction potential by application of the isoinversion principle and the structure–selectivity relationship of the cyclohexanol auxiliaries. A simple preparation of both enantiomers of 1 is possible on a large scale by the enzymatic saponification of a technical‐grade product.