Premium
A Short Diastereoselective Entry to Indole Alkaloids of the Corynanthe Type by the Intramolecular Ene Reaction
Author(s) -
Tietze Lutz F.,
Wichmann Jürgen
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199210791
Subject(s) - intramolecular force , ene reaction , indole test , trifluoroacetic acid , chemistry , stereoselectivity , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
Biologically active indole alkaloids are accessible in a convergent and stereoselective fashion by the sequential intramolecular ene reaction of starting compounds such as 1 . The first cyclization to 2 in this one‐pot procedure is triggered by trifluoroacetic acid, the second by SnCl 4 .
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom