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[RuO(dppz)(tpy)] 2+ : a DNA Cleavage Agent with High DNA Affinity
Author(s) -
Gupta Nishi,
Grover Neena,
Neyhart Gregory A.,
Liang Weigen,
Singh Phirtu,
Thorp H. Holden
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199210481
Subject(s) - chemistry , intercalation (chemistry) , dna , cleavage (geology) , stereochemistry , acridine , stacking , counterion , terpyridine , crystallography , combinatorial chemistry , ion , biochemistry , biology , organic chemistry , fracture (geology) , metal , paleontology
A Ru IV O functional unit and an intercalating heteroligand , dipyridophenazine (dppz), are united in the complex cation of the title, 1 , and responsible for its high DNA‐cleavage activity and DNA affinity. In the solid state, the units of the RuOH 2 analogue of 1 (C1O 4 −counterion) are linked by π‐stacking interactions similar to those in acridine orange and other conventional intercalators; the distance between the dppz ligands is 3.5 Å. tpy = 2,2′,2″‐terpyridine.