[RuO(dppz)(tpy)] 2+  : a DNA Cleavage Agent with High DNA Affinity | Zendy

Gupta Nishi | Zendy; Grover Neena | Zendy; Neyhart Gregory A. | Zendy; Liang Weigen | Zendy; Singh Phirtu | Zendy; Thorp H. Holden | Zendy

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[RuO(dppz)(tpy)] 2+ : a DNA Cleavage Agent with High DNA Affinity

Author(s) -

Gupta Nishi,

Grover Neena,

Neyhart Gregory A.,

Liang Weigen,

Singh Phirtu,

Thorp H. Holden

Publication year - 1992

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199210481

Subject(s) - chemistry , intercalation (chemistry) , dna , cleavage (geology) , stereochemistry , acridine , stacking , counterion , terpyridine , crystallography , combinatorial chemistry , ion , biochemistry , biology , organic chemistry , fracture (geology) , metal , paleontology

A Ru IV O functional unit and an intercalating heteroligand , dipyridophenazine (dppz), are united in the complex cation of the title, 1 , and responsible for its high DNA‐cleavage activity and DNA affinity. In the solid state, the units of the RuOH 2 analogue of 1 (C1O 4 −counterion) are linked by π‐stacking interactions similar to those in acridine orange and other conventional intercalators; the distance between the dppz ligands is 3.5 Å. tpy = 2,2′,2″‐terpyridine.

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