Premium
Synthetic Chain‐Substituted Phospholipids: Ion Transport Across Their Bilayer Membranes
Author(s) -
Menger Fredric M.,
Aikens Patricia
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199208981
Subject(s) - vesicle , phospholipid , alkyl , membrane , bilayer , chemistry , lipid bilayer , ion , flux (metallurgy) , fluorescence , biophysics , ion transporter , organic chemistry , biochemistry , biology , physics , quantum mechanics
The passage of ions through phospholipid vesicles is facilitated by building alkyl substituents into the lipid chains. The effect of the size, position, and number of substituents on the ion flux can be studied by monitoring the decrease in fluorescence of a pH‐sensitive dye within the vesicles on lowering the pH of the surrounding water. Substituents in the middle of the chains were most efficient in altering the flux. Such studies are of interest for the development of systems for controlled drug release.